Peptide capsules, and why so few
Most peptides do not survive the stomach. The ones that appear in capsule form are here because something about their structure or their target makes the oral route worth investigating at all.
A peptide is food to a protease
The digestive tract is very good at taking chains of amino acids apart. That is literally its job. A peptide swallowed as-is meets stomach acid first and a wall of proteolytic enzymes second, and most of them do not come out the other side intact enough to be worth measuring.
There are two ways around it. Either the sequence is unusually resistant, or the target sits in the gut itself, so degradation on the way to the bloodstream is beside the point. Both of the products on this page fall into one of those two categories.
Anyone offering you a long list of oral peptides is either using enteric coating claims they cannot support, or is not being straight with you about what happens after the capsule dissolves.
What decides whether oral works
- Chain length — shorter sequences fare better
- Whether the target is in the gut or past it
- Resistance to proteolytic cleavage
- Whether the literature measured anything at all after oral use
Research context only. This is not a statement about effects in people.
Capsules and the solvent
Two capsule products, plus the bacteriostatic water that every reconstitution step needs.
Related reading
Where these compounds sit in the wider literature.
BPC-157
Derived from a protein found in gastric juice, which is exactly why the gut is a plausible place to study it.
Read CategoryCollagen peptides
The best known oral peptide of all, and a useful illustration of why it sits in a completely different legal category.
Read PracticeBacteriostatic water
Benzyl alcohol is the whole difference. What that changes for a vial you open more than once.
ReadAbout the oral format
What people ask about capsules specifically.
Why can I not get every peptide as a capsule?
Does an enteric coating solve the problem?
How should capsules be stored?
Is bacteriostatic water a capsule product?
Short list, honest reasons
Two capsule products, both released at 99% or higher by HPLC with the certificate available per batch. The rest of the catalogue is in formats where the evidence actually supports them.
For laboratory and research use only. Not for human or animal consumption. Not a medicine and not a food supplement. Sold to persons aged 18 and over.
